PMID: Evid Based Complement Alternat Med. 2021 ;2021:4514342. Epub 2021 Aug 26. PMID: 34484390 Abstract Title: A Review: Mechanism ofin Cancers-NF-B, P13K/AKT, and MAPKs Signaling Activation. Abstract: has been characterized for its several biological and medicinal effects such as antiviral, antibacterial, anti-inflammatory, anticancer, and immunoregulation. In recent years,has demonstrated potential to modulate the activation of critical pathways such as NF-B, P13K/AKT, and ERK/JNK/P38/MAPKs associated with cell growth, proliferation, metastasis, and apoptotic cell death. To date, there is much evidence indicating that modulation of cellular signaling pathways is a promising approach to consider in drug development and discovery. Thus, therapies that can regulate cancer-related pathways are longed-for in anticancer drug discovery. This review's focus is to provide comprehensive knowledge on the anticancer mechanisms ofthrough the regulation of NF-B, P13K/AKT, and ERK/JNK/P38/MAPKs signaling pathways. Thus, the review summarizes both in vitro and in vivo effects ofextracts or bioactive constituents with emphasis on tumor cell apoptosis. The literature information was obtained from publications on Google Scholar, PubMed, Web of Science, and EBSCOhost. The key words used in the search were "or "and cancer.inhibits cancer cell proliferation via inhibition of NF-B, P13K/AKT, and MAPKs (ERK, JNK, P38) pathways to induce apoptosis and prevents angiogenesis. It is expected that understanding these fundamental mechanisms may help stimulate additional research to exploitand other natural products for the development of novel anticancer therapies in the future.
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