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Heath
Alternative Medicine
Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway.
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[QUOTE="greenmedinfo, post: 1559"] PMID: Sci Rep. 2021 04 22 ;11(1):8754. Epub 2021 Apr 22. PMID: 33888745 Abstract Title: Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway. Abstract: Psoralen is one of the most effective ingredients extracted from the Chinese herb, Psoralea corylifolia L. Studies have found that psoralen has anti-inflammatory and estrogen-like effects; however, little research has been conducted to elucidate the mechanisms underlying these effects. Through the molecule docking assay, psoralen was found to have a better combination with ERα than ERβ. In human periodontal ligament cells, psoralen was found to upregulate the estrogen target genes (e.g., CTSD, PGR, TFF1) and down-regulate the expression of inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-8) stimulated by P. gingivalis LPS, as well as TLR4-IRAK4-NF-κb signaling pathway proteins. These effects were reversed by the ER antagonist ICI 182780. These results indicated that psoralen may exert anti-inflammatory effects as an agonist to ER, which could provide a theoretical basis for the use of psoralen for adjuvant therapy and prevention of periodontitis. [URL='https://www.greenmedinfo.com/article/anti-inflammatory-activity-psoralen-human-periodontal-ligament-cells-estrogen-']read more[/URL] [/QUOTE]
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Heath
Alternative Medicine
Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway.
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