PMID: Antibiotics (Basel). 2021 Nov 7 ;10(11). Epub 2021 Nov 7. PMID: 34827297 Abstract Title: Antifungal and Anti-Biofilm Effects of Caffeic Acid Phenethyl Ester on DifferentSpecies. Abstract: This study investigated the effect of CAPE on planktonic growth, biofilm-forming abilities, mature biofilms, and cell death of,,, andstrains. Our results showed a strain- and dose-dependent effect of CAPE on, and the MIC values were between 12.5 and 100µg/mL. Similarly, the MBIC values of CAPE ranging between 50 and 100 µg/mL highlighted the inhibition of the biofilm-forming abilities in a dose-dependent manner, as well. However, CAPE showed a weak to moderate biofilm eradication ability (19-49%) on differentstrains mature biofilms. Both caspase-dependent and caspase-independent apoptosis after CAPE treatment were observed in certain testedstrains. Our study has displayed typical apoptotic hallmarks of CAPE-induced chromatin margination, nuclear blebs, nuclear condensation, plasma membrane detachment, enlarged lysosomes, cytoplasm fragmentation, cell wall distortion, whole-cell shrinkage, and necrosis. In conclusion, CAPE has a concentration and strain-dependent inhibitory activity on viability, biofilm formation ability, and cell death response in the differentspecies.
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