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Heath
Alternative Medicine
COVID-19 and IL-6: Why vitamin D probably helps but tocilizumab might not.
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<blockquote data-quote="greenmedinfo" data-source="post: 617"><p>PMID: Eur J Pharmacol. 2021 May 15 ;899:174031. Epub 2021 Mar 13. PMID: 33722593 Abstract Title: COVID-19 and IL-6: Why vitamin D (probably) helps but tocilizumab might not. Abstract: Interleukin 6 (IL-6), which is involved in the cytokine storm phenomenon, is a therapeutic target in COVID-19, but monoclonal receptor antibody therapeutic agents such as tocilizumab have demonstrated mixed results. Could Vitamin D, which modulates IL-6, be more effective than currently deployed IL-6 antagonists, including tocilizumab, thereby presenting a useful therapeutic option in COVID-19? A narrative review of published trials examining the effect of Vitamin D administration in COVID-19 patients was conducted, and the theoretical basis for the use of tocilizumab as an IL-6 antagonist was compared with the immunomodulatory effect of Vitamin D on IL-6 production. Four of the six included studies reported a positive effect of Vitamin D on outcomes. While tocilizumab non-selectively blocks both anti-inflammatory and pro-inflammatory actions of IL-6, Vitamin D lowers immune cell IL-6 production, potentially reducing pro-inflammatory effects, but does not specifically target IL-6 receptors, avoiding any deleterious effect on the anti-inflammatory actions of IL-6. Vitamin D may have advantages over tocilizumab as an IL-6 immunomodulator, and, given that it is safe if administered under clinical supervision, there is a strong rationale for its use. </p><p><a href="https://www.greenmedinfo.com/article/covid-19-and-il-6-why-vitamin-d-probably-helps-tocilizumab-might-not" target="_blank">read more</a></p></blockquote><p></p>
[QUOTE="greenmedinfo, post: 617"] PMID: Eur J Pharmacol. 2021 May 15 ;899:174031. Epub 2021 Mar 13. PMID: 33722593 Abstract Title: COVID-19 and IL-6: Why vitamin D (probably) helps but tocilizumab might not. Abstract: Interleukin 6 (IL-6), which is involved in the cytokine storm phenomenon, is a therapeutic target in COVID-19, but monoclonal receptor antibody therapeutic agents such as tocilizumab have demonstrated mixed results. Could Vitamin D, which modulates IL-6, be more effective than currently deployed IL-6 antagonists, including tocilizumab, thereby presenting a useful therapeutic option in COVID-19? A narrative review of published trials examining the effect of Vitamin D administration in COVID-19 patients was conducted, and the theoretical basis for the use of tocilizumab as an IL-6 antagonist was compared with the immunomodulatory effect of Vitamin D on IL-6 production. Four of the six included studies reported a positive effect of Vitamin D on outcomes. While tocilizumab non-selectively blocks both anti-inflammatory and pro-inflammatory actions of IL-6, Vitamin D lowers immune cell IL-6 production, potentially reducing pro-inflammatory effects, but does not specifically target IL-6 receptors, avoiding any deleterious effect on the anti-inflammatory actions of IL-6. Vitamin D may have advantages over tocilizumab as an IL-6 immunomodulator, and, given that it is safe if administered under clinical supervision, there is a strong rationale for its use. [URL='https://www.greenmedinfo.com/article/covid-19-and-il-6-why-vitamin-d-probably-helps-tocilizumab-might-not']read more[/URL] [/QUOTE]
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Alternative Medicine
COVID-19 and IL-6: Why vitamin D probably helps but tocilizumab might not.
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