PMID: J BUON. 2021 Nov 1 ;26. Epub 2021 Nov 1. PMID: 34812147 Abstract Title: Vitamin C through upregulating SYNPO2 level suppresses the proliferation and migration of glioma cells. Abstract: PURPOSE: The aim was to demonstrate the progression of glioma influenced by Vitamin C (VC) and the potential molecular mechanism.METHODS: Proliferative and migratory rates of U87 and U251 cells induced with 0, 50 and 100µM VC were examined by CCK-8 and Transwell assay, respectively. Clinical significance of SYNPO2 in glioma patients was analyzed. Relative level of SYNPO2 in VC-induced glioma cells was detected. By intervening SYNPO2, the involvement of SYNPO2 in the anti-cancer role of VC in inhibiting glioma cellphenotypes was finally confirmed.RESULTS: VC induction dose-dependently attenuated proliferative and migratory potentials of glioma cells. A low level of SYNPO2 indicated poor prognosis of glioma. Protein and mRNA levels of SYNPO2 were upregulated in glioma cells induced with VC. The inhibitory effects of VC on proliferative and migratory potentials of glioma cells were partially reversed by knockdown of SYNPO2.CONCLUSIONS: VC blocks glioma cells to proliferate and migrate by upregulating SYNPO2.
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