PMID: Vet World. 2021 Oct ;14(10):2699-2704. Epub 2021 Oct 22. PMID: 34903928 Abstract Title: Wound healing by topical application ofL. formulations on mice. Abstract: Background and Aim: is mainly characterized by its antimicrobial and antioxidant properties. The current study aimed to evaluate the healing activity of gel and cream formulations based onon induced wounds in mice.Materials and Methods: Acetonic extract ofwas prepared and incorporated into gel and cream formulations.Balb/c (n=30) with induced injury were distributed into five groups: Group I (control - day 7), Group II (control - day 14), Group III (1% gel - day 7), and Group IV (1% gel - day 14) to which 1%gel was dermally applied daily for 7 and 14 days, respectively, Group V (1% cream - day 7) and Group VI (1% cream - day 14) to which of1% cream were dermally applied daily for 7 and 14 days, respectively. Time of wound closure was determined during the experimentation; rats were euthanized with sodium pentobarbital 60 mg/kg/pc v.ip. for obtaining skin samples for histopathological analysis.Results: Groups IV and VI showed a higher percentage of wound closure on day 14, and in histopathological analysis, effect was greater in Group VI with the presence of fibroblasts and abundant collagen and elastic fibers.Conclusion: gel and cream showed wound healing activity on induced wounded mice; the most effective treatment was1% cream formulation.
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