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    Naringenin protects swine testis cells from bisphenol A-induced apoptosis via Keap1/Nrf2 signaling pathway.

    PMID: Biofactors. 2021 Dec 16. Epub 2021 Dec 16. PMID: 34914851 Abstract Title: Naringenin protects swine testis cells from bisphenol A-induced apoptosis via Keap1/Nrf2 signaling pathway. Abstract: Bisphenol A (BPA) has caused serious pathologies in varying organs of humans and animals...
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    Tanshinone IIA improves degranulation of mast cells and allergic rhinitis induced by ovalbumin.

    PMID: Hum Exp Toxicol. 2021 Dec ;40(12_suppl):S702-S710. Epub 2021 Nov 18. PMID: 34792426 Abstract Title: Tanshinone IIA improves degranulation of mast cells and allergic rhinitis induced by ovalbumin by inhibiting the PLCγ1/PKC/IP3R pathway. Abstract: Allergic rhinitis (AR) is a common...
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    Tanshinone IIA attenuates high glucose-induced epithelial-to-mesenchymal transition in HK-2 cells through VDR/Wnt/β-catenin signaling pathway.

    PMID: Folia Histochem Cytobiol. 2021 Dec 2. Epub 2021 Dec 2. PMID: 34852178 Abstract Title: Tanshinone IIA attenuates high glucose-induced epithelial-to-mesenchymal transition in HK-2 cells through VDR/Wnt/β-catenin signaling pathway. Abstract: INTRODUCTION: The progression of diabetic kidney...
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    Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells.

    PMID: Tissue Cell. 2021 Nov 27 ;74:101705. Epub 2021 Nov 27. PMID: 34864499 Abstract Title: Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells. Abstract: Osteosarcoma is the most common type of bone cancer, and metastasis is widespread decreasing the...
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    Polyphenol-enriched blueberry preparation controls breast cancer stem cells by targeting FOXO1 and miR-145.

    PMID: Molecules. 2021 Jul 17 ;26(14). Epub 2021 Jul 17. PMID: 34299605 Abstract Title: Polyphenol-Enriched Blueberry Preparation Controls Breast Cancer Stem Cells by Targeting FOXO1 and miR-145. Abstract: Scientific evidence supports the early deregulation of epigenetic profiles during breast...
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    Taken together this data suggests that blueberry extract exerts some selective anticancer activity in C6 glioma cells.

    PMID: Metab Brain Dis. 2021 Nov 8. Epub 2021 Nov 8. PMID: 34748129 Abstract Title: Selective in vitro anticancer effect of blueberry extract (Vaccinium virgatum) against C6 rat glioma: exploring their redox status. Abstract: The aim of this study was to investigate the anticancer potential of...
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    Ex vivo treatment with fucoidan of mononuclear cells from SARS-CoV-2 infected patients.

    PMID: Int J Environ Health Res. 2021 Oct 24:1-19. Epub 2021 Oct 24. PMID: 34689674 Abstract Title: treatment with fucoidan of mononuclear cells from SARS-CoV-2 infected patients. Abstract: COVID-19 is a worldwide health emergency, therapy for this disease is based on antiviral drugs and...
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    Inhibition of fucoidan on breast cancer cells and potential enhancement of their sensitivity to chemotherapy by regulating autophagy.

    PMID: Phytother Res. 2021 Oct 23. Epub 2021 Oct 23. PMID: 34687482 Abstract Title: Inhibition of fucoidan on breast cancer cells and potential enhancement of their sensitivity to chemotherapy by regulating autophagy. Abstract: Fucoidan is a marine-origin sulfated polysaccharide that has...
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    Lycium barbarum polysaccharide protects ARPE‑19 cells against H 2 O 2‑induced oxidative stress via the Nrf2/HO‑1 pathway.

    PMID: Mol Med Rep. 2021 11 ;24(5). Epub 2021 Sep 7. PMID: 34490478 Abstract Title: Lycium barbarum polysaccharide protects ARPE‑19 cells against HO‑induced oxidative stress via the Nrf2/HO‑1 pathway. Abstract: Age‑related macular degeneration (AMD) is a global health problem. Lycium barbarum...
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    A natural product, Piperlongumine (PL), increases tumor cells sensitivity to NK cell killing.

    PMID: Int Immunopharmacol. 2021 Jul ;96:107658. Epub 2021 Apr 19. PMID: 33887610 Abstract Title: A natural product, Piperlongumine (PL), increases tumor cells sensitivity to NK cell killing. Abstract: Natural Killer (NK) cells are components of innate immune surveillance against transformed...
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    Piperlongumine promotes death of retinoblastoma cancer cells.

    PMID: Oncotarget. 2021 Apr 27 ;12(9):907-916. Epub 2021 Apr 27. PMID: 33953844 Abstract Title: Piperlongumine promotes death of retinoblastoma cancer cells. Abstract: Retinoblastoma is the most common pediatric intraocular malignant tumor. While retinoblastoma initiation is triggered by the...
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    Piperlongumine inhibits migration and proliferation of castration-resistant prostate cancer cells via triggering persistent DNA damage.

    PMID: BMC Complement Med Ther. 2021 Jul 6 ;21(1):195. Epub 2021 Jul 6. PMID: 34229670 Abstract Title: Piperlongumine inhibits migration and proliferation of castration-resistant prostate cancer cells via triggering persistent DNA damage. Abstract: BACKGROUND: Metastatic castration-resistant...
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    Low-dose piperlongumine rescues impaired function of endothelial progenitor cells and reduces cerebral ischemic injury.

    PMID: Front Pharmacol. 2021 ;12:689880. Epub 2021 Nov 15. PMID: 34867315 Abstract Title: Low-Dose Piperlongumine Rescues Impaired Function of Endothelial Progenitor Cells and Reduces Cerebral Ischemic Injury in High-Fat Diet-Fed Mice. Abstract: It is of great clinical significance to develop...
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    The impact of harmine hydrochloride on growth, apoptosis and migration, invasion of gastric cancer cells.

    PMID: Pathol Res Pract. 2020 Aug ;216(8):152995. Epub 2020 Apr 25. PMID: 32402536 Abstract Title: The impact of Harmine hydrochloride on growth, apoptosis and migration, invasion of gastric cancer cells. Abstract: It has been reported that Harmine hydrochloride (HH) has an inhibitory effect...
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    Harmine inhibits the proliferation and migration of glioblastoma cells via the FAK/AKT pathway.

    PMID: Life Sci. 2021 Apr 1 ;270:119112. Epub 2021 Jan 26. PMID: 33508300 Abstract Title: Harmine inhibits the proliferation and migration of glioblastoma cells via the FAK/AKT pathway. Abstract: AIMS: Glioblastoma is one of the most invasive tumors of the central nervous system, and has a...
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    Harmine hydrochloride mediates the induction of G2/M Cell cycle arrest in breast cancer cells.

    PMID: Molecules. 2021 Nov 5 ;26(21). Epub 2021 Nov 5. PMID: 34771123 Abstract Title: Harmine Hydrochloride Mediates the Induction of G2/M Cell Cycle Arrest in Breast Cancer Cells by Regulating the MAPKs and AKT/FOXO3a Signaling Pathways. Abstract: Breast cancer (BC) is one of the most common...
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    Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells.

    PMID: Nan Fang Yi Ke Da Xue Xue Bao. 2021 Apr 20 ;41(4):475-482. PMID: 33963705 Abstract Title: [Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by blocking spike protein-mediated membrane fusion]. Abstract: OBJECTIVE: The investigate the inhibitory...
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    Crocetin attenuating Urinary tract Infection and adherence of uropathogenic E. coli in NRK-52E cells via an inflammatory pathway.

    PMID: J Food Biochem. 2021 Nov 18:e13998. Epub 2021 Nov 18. PMID: 34792197 Abstract Title: Crocetin attenuating Urinary tract Infection and adherence of uropathogenic E. coli in NRK-52E cells via an inflammatory pathway. Abstract: BACKGROUND AND OBJECTIVE: Urinary tract infections (UTI) are...
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    Identification of renoprotective phytosterols from mulberry fruit against cisplatin-induced cytotoxicity in LLC-PK1 kidney cells.

    PMID: Plants (Basel). 2021 Nov 17 ;10(11). Epub 2021 Nov 17. PMID: 34834844 Abstract Title: Identification of Renoprotective Phytosterols from Mulberry () Fruit against Cisplatin-Induced Cytotoxicity in LLC-PK1 Kidney Cells. Abstract: The aim of this study was to explore the protective...
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    Constituents of Morus alba var. multicaulis leaf improve lipid metabolism by activating the AMPK signaling pathway in HepG2 cells.

    PMID: J Nat Med. 2021 Nov 6. Epub 2021 Nov 6. PMID: 34743295 Abstract Title: Constituents of Morus alba var. multicaulis leaf improve lipid metabolism by activating the AMPK signaling pathway in HepG2 cells. Abstract: One new compound, 3Z-1-O-β-D-glucopyranosyl-3-hexene-1,5-diol (1), together...
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