PMID: Ann Transl Med. 2021 Sep ;9(18):1435. PMID: 34733987 Abstract Title: Astragaloside IV protects cardiomyocytes against hypoxia injury viaand thepathway. Abstract: Background: Hypoxia is an important cause of myocardial injury due to the heart's high susceptibility to hypoxia. Astragaloside IV (AS-IV) is the main component ofand could exert cardiac protective role. Here, the effect of AS-IV on hypoxia-injured H9c2 cardiomyocytes was elucidated.Methods: First, H9c2 cells were exposed to hypoxia and/or AS-IV treatment. Cell apoptosis, death, and viability as well as() expression and apoptotic proteins were analyzed. Next, transfection of si-into H9c2 cells was carried out to test whether upregulation and stabilization ofinfluences the effect of AS-IV on hypoxia-treated H9c2 cells. Furthermore, the regulatory role of() signaling onlevels was examined.Results: Hypoxia suppressed viability and promoted the apoptosis and death of H9c2 cells. AS-IV eliminated hypoxia-induced H9c2 injury. Moreover,signaling was further activated and stabilized by AS-IV in hypoxia-challenged H9c2 cells. Downregulation ofsuppressed the function of AS-IV in hypoxia-challenged H9c2 cells. AS-IV promotedsignaling in hypoxia-induced injury. The beneficial functions of AS-IV in hypoxia-exposed H9c2 cells were linked toupregulation andsignaling activation.Conclusions: AS-IV relieved H9c2 cardiomyocyte injury after hypoxia, possibly by activating-mediatedsignaling.
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